The expected response to the situation from the city has already been made clear: Pretty much every cape
with a scrap of decency and courage, be they hero or villain (or even rogues, probably), does their darndest to protect the city and put down the Endbringer. I don’t think that will be subverted in this case.
As for fallout, I think we might be in for lots of death and destruction. It might include some characters we already know among the death toll, which is something this story has yet to do.
Basically, I think this might be where shit gets even more real than it’s been thus far, and your ask does nothing to dissuade that impression.